Priyamani was born in an Iyer family in Palakkad, Kerala, and grew up in Bangalore. As a result of her dynamic exposure in different South Indian states, she speaks Kannada, Tamil, Malayalam, and Telugu. After completing her schooling, Priyamani modeled for print advertisements. As a subsequent result of her extended modeling, she began to earn opportunities to star in films.
After being approached by several directors and being considered for roles, she finally starred in director Bharathiraja's film Kangalal Kaidhu Sei, which was released in 2004.[1] She is currently completing a B.A. in Psychology. She is the cousin of Bollywood actress Vidya Balan
Her debut film Kangalal Kaidhu Sei in Tamil was released in 2004, and her Telugu debut, Evare Atagaadu, sank without a trace. Priyamani then made her debut in the Malayalam film industry, where she starred opposite Prithviraj, through the film Satyam, but this film also performed poorly at the box office. Despite these commercial failures, she was signed by Tamil film director and cinematographer Balu Mahendra to star opposite Dhanush in the 2005 drama Adhu Oru Kana Kaalam. She won tremendous acclaim for her performance in the film, but the film's under-performance meant that box office success still eluded her.